Presence and localization of a 30-kDa basic fibroblast growth factor-like protein in rodent testes

We have used a recently characterized rabbit antiserum against basic fibroblast growth factor (bFGF), which recognizes various forms of bFGF, to examine the presence and localization of bFGF in the testes of adult rats and mice and the 5-day-old rat. In Western blots of testicular homogenates of adult rats and mice and immature rats, immunoreactive single bands at approximately 30 kDa were detected. Immunocytochemistry revealed specific staining restricted to the tubular compartment. In 5-day-old rat testes, prespermatogonia were immunoreactive. The cytoplasm of pachytene spermatocytes was heavily stained in the adult testes of both species. Staining of these cells became evident around stage IV/V, was prominent in stage VII through IX and declined about stage XII/XIII (rat) or X-XI (mouse). Staining was seen in type A spermatogonia and in elongating spermatids in their cytoplasmatic lobes and along their flagellae. Sertoli cells were unstained. We propose that the pluripotential growth factor bFGF could be involved in the regulation of germ cell proliferation and differentiation in the adult and immature testis

Engineering a ROVER language in GEMOC STUDIO & MONTICORE: A comparison of language reuse support

Domain-specific languages (DSLs) improve engineering productivity through powerful abstractions and automation. To support the development of DSLs, the software language engineering (SLE) community has produced various solutions for the systematic engineering of DSLs that manifest in language workbenches. In this paper, we investigate the applicability of the language workbenches GEMOC STUDIO and MONTICORE to the MDETools’17 ROVER challenge. To this effect, we refine the challenge’s requirements and show how GEMOC STUDIO and MONTICORE can be leveraged to engineer a Rover-specific DSL by reusing existing DSLs and tooling of GEMOC STUDIO and MONTICORE. Through this, we reflect on the SLE state of the art, detail capabilities of the two workbenches focusing particularly on language reuse support, and sketch how modelers can approach ROVER programming with modern modeling tools

The nucleus ^198 Au investigated with neutron capture and transfer reactions. II. Construction of the level scheme and calculation of level densities

The level scheme of ^198 Au was constructed. Up to 1560 keV a total of 111 (d,p) and 125 (n,gamma) levels was included, frequently with spin and parity assignments. The results for level densities are calculated in interacting boson-fermion-fermion model (IBFFM) and Gaussian polynomial method (GPM) and are compared to the present data

The nucleus ^198 Au investigated with neutron capture and transfer reactions I. Experiments and evaluation

The transfer reaction ^197 Au(d,p)^198 Au was measured at the Tandem Accelerator in Munich. The ^197 Au(n,gamma)^198 Au and ^197 Au(n,e)^198 Au reactions were performed at the High Flux Reactor of ILL, Grenoble. Up to 1560 keV a total of 111 levels were observed by the (d,p) reaction and 125 by the (n,gamma) reaction. For many of the levels, spins and parities were assigned. Additional information was obtained from summed (n,gamma gamma) coincidences measured in Dubna

Proučavanje jezgre 198Au pomoću neutronskog uhvata i (d,p) reakcijom. II. Konstrukcija sheme nivoa i izračunavanje gustoće nivoa

The level scheme of 198Au was constructed. Up to 1560 keV a total of 111 (d,p) and 125 (n,γ) levels was included, frequently with spin and parity assignments. The results for level densities are calculated in interacting boson–fermion–fermion model (IBFFM) and Gaussian polynomial method (GPM) and are compared to the present data.Sastavljena je shema raspada 198Au. Do energije uzbude od 1560 keV, uključeno je 111 stanja određenih (d,p) reakcijom i 125 stanja (n,γ) reakcijom. Za mnoga stanja određeni su momenti impulsa i parnost. Primjenom modela uzajamno djelujućih bozon–fermion–fermiona i metode Gaussovih polinoma, izračunate su gustoće stanja i uspoređene s izmjerenim vrijednostima

Proučavanje jezgre 198au pomoću neutronskog uhvata i (d,p) reakcijom. I. Eksperimenti i procjena

The transfer reaction 197Au(d,p)198Au was measured at the Tandem Accelerator in Munich. The 197Au(n,γ) 198Au and 197Au(n,e)198Au reactions were performed at the High Flux Reactor of ILL, Grenoble. Up to 1560 keV a total of 111 levels were observed by the (d,p) reaction and 125 by the (n,γ) reaction. For many of the levels, spins and parities were assigned. Additional information was obtained from summed (n,γγ) coincidences measured in Dubna.Načinjena su mjerenja relacije 197Au(d,p)198Au pomoću tandem Van de Graaff akceleratora u Munchenu, a reakcije 197Au(n,γ) 198Au i 197Au(n,e)198Au proučavane su pri nuklearnom reaktoru u Institutu Lane–Laugevin u Grenoblu. Reakcijom (d,p) opaženo je do energije uzbude od 156 keV ukupno 111 nivoa, a reakcijom (n,γ) 125 nivoa. Za mnoge nivoe utvrđeni su momenti impulsa i parnosti. Dodatni su podaci postignuti mjerenjem zbrojnih (n,γγ) sudara u Institutu u Dubni

Proučavanje jezgre 198au pomoću neutronskog uhvata i (d,p) reakcijom. I. Eksperimenti i procjena

The transfer reaction 197Au(d,p)198Au was measured at the Tandem Accelerator in Munich. The 197Au(n,γ) 198Au and 197Au(n,e)198Au reactions were performed at the High Flux Reactor of ILL, Grenoble. Up to 1560 keV a total of 111 levels were observed by the (d,p) reaction and 125 by the (n,γ) reaction. For many of the levels, spins and parities were assigned. Additional information was obtained from summed (n,γγ) coincidences measured in Dubna.Načinjena su mjerenja relacije 197Au(d,p)198Au pomoću tandem Van de Graaff akceleratora u Munchenu, a reakcije 197Au(n,γ) 198Au i 197Au(n,e)198Au proučavane su pri nuklearnom reaktoru u Institutu Lane–Laugevin u Grenoblu. Reakcijom (d,p) opaženo je do energije uzbude od 156 keV ukupno 111 nivoa, a reakcijom (n,γ) 125 nivoa. Za mnoge nivoe utvrđeni su momenti impulsa i parnosti. Dodatni su podaci postignuti mjerenjem zbrojnih (n,γγ) sudara u Institutu u Dubni

Weaving Concurrency in eXecutable Domain-Specific Modeling Languages

International audienceThe emergence of modern concurrent systems (e.g., Cyber-Physical Systems or the Internet of Things) and highly-parallel platforms (e.g., many-core, GPGPU pipelines, and distributed platforms) calls for Domain-Specific Modeling Languages (DSMLs) where concurrency is of paramount importance. Such DSMLs are intended to propose constructs with rich concurrency semantics, which allow system designers to precisely define and analyze system behaviors. However , specifying and implementing the execution semantics of such DSMLs can be a difficult, costly and error-prone task. Most of the time the concurrency model remains implicit and ad-hoc, embedded in the underlying execution environment. The lack of an explicit concurrency model prevents: the precise definition, the variation and the complete understanding of the semantics of the DSML, the effective usage of concurrency-aware analysis techniques, and the exploitation of the concurrency model during the system refinement (e.g., during its allocation on a specific platform). In this paper, we introduce a concurrent executable metamodeling approach, which supports a modular definition of the execution semantics , including the concurrency model, the semantic rules, and a well-defined and expressive communication protocol between them. Our approach comes with a dedicated metalanguage to specify the communication protocol, and with an execution environment to simulate executable models. We illustrate and validate our approach with an implementation of fUML, and discuss the modularity and applicability of our approach

Predicted mechanisms of resistance to mTOR inhibitors

The serine/threonine kinase, mTOR (mammalian Target of Rapamycin) has become a focus for cancer drug development. Rapamycins are highly specific inhibitors of mTOR and potently suppress tumour cell growth by retarding cells in G1 phase or potentially inducing apoptosis. Currently, both rapamycin and several analogues are being evaluated as anticancer agents in clinical trials. Results indicate that many human cancers have intrinsic resistance and tumours initially sensitive to rapamycins become refractory, demonstrating acquired resistance. Here, we consider mechanisms of resistance to inhibitors of mTOR

Proučavanje 194Ir uhvatom termičkih neutrona I (d, p) reakcijom

Levels of 194Ir were studied using thermal neutron capture reaction. A pair spectrometer was used to measure the high-energy γ-ray spectrum from thermal-neutron capture in enriched 193Ir target over the energy range 4640 - 6100 keV. The low-energy γ-radiation from the reaction was studied with crystal diffraction spectrometers, and conversion electrons were observed with magnetic spectrometers. The high-sensitivity measurements at the Grenoble reactor, evaluated for transition energies up to 500 keV, are compared with lower-sensitivity measurements at the Wuerenlingen and Salaspils reactors. The comparison helped to obtain reliable isotopic identification for a number of 194Ir lines. The multipolarity admixtures for 29 γ-transitions were determined on the basis of conversion lines from different electron subshells. Prompt and delayed γ-γ coincidences were measured using semiconductor and scintillation detectors. The 193Ir(d,p) high-resolution spectra, observed with a magnetic spectrometer, are given. All these data contributed to establishing a detailed level scheme of 194Ir. Additional data and the interpretation of the results in terms of current models will be presented in a forthcoming paper.Proučavala su se stanja u 194Ir reakcijama 193Ir(n, γ) i 193Ir(d, p). Mjerenja uhvata termičkih neutrona načinjena su uz reaktore u Grenoblu, Wuerenlingenu i Salapsisu. Za mjerenja γ-zračenja visoke energije upotrebljavao se spektrometar parova, a za niske energije difraktometar. Konverzijske elektrone se mjerilo magnetskim spektrometrom. Mjerenja reakcije (d, p) visokog razlučivanja izvedena su magnetskim spektrometrom. Usporedbe tih mjerenja omogućile su pouzdano izotopno prepoznavanje prijelaza u 194 Ir, a spektri konverzijskih elektrona i određivanje multipolnosti prijelaza. Dobiveni su podaci osnova sheme raspada 194Ir